Certified Clinical Research Associate (CCRA) Practice Exam 2025 – All-in-One Guide to Master Your Certification!

A superiority trial is specifically designed with the objective of demonstrating that a new treatment or intervention is more effective than a control treatment, which may be another active treatment or a placebo. The primary aim is to establish a statistically significant improvement in outcomes with the experimental treatment compared to the control.

In the context of clinical research, this type of trial is crucial when the goal is to provide evidence that supports the use of a new therapy due to its superior efficacy. This often involves a rigorous study design with appropriate sample sizing and statistical analyses tailored to validate the hypothesis of superiority.

The other options highlight different types of trials that do not align with the clear intent of establishing superiority. For example, a trial designed to show non-inferiority focuses on demonstrating that a new treatment is at least as effective as a control rather than better. Similarly, trials focused solely on safety or that do not treat or observe patients directly serve different research purposes and are not aimed at proving superiority.